911690

C5 Lenalidomide

≥95%

• Synonyme(s) : 3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, E3 ligase ligand, Ligand for PROTAC^® research
• Formule empirique (notation de Hill): C₁₃H₁₃N₃O₃
• Numéro CAS: 191732-70-4
• Poids moléculaire : 259.26
• Numéro MDL: MFCD31692701
• Code UNSPSC : 12352101
• Nomenclature NACRES : NA.22

Propriétés

• ligand: C5 Lenalidomide
• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: powder
• Pertinence de la réaction: reagent type: ligand
• Température de stockage: 2-8°C
• Chaîne SMILES: NC1=CC=C2C(CN(C3CCC(NC3=O)=O)C2=O)=C1

Description

Application

C5 Lenalidomide is a derivative of the Cereblon (CRBN)-binding ligand lenalidomide, which possesses an amine at the C4 position. C5 Lenalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis of protein degraders with a C5 exit vector. Learn more about proteolysis-targeting chimeras (PROTACs) and the building blocks to design them in our Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Autres remarques

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

Targeted Protein Degradation by Small Molecules

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H361d,H373
• Conseils de prudence: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 2 - STOT RE 2
• Organes cibles: Blood
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable