585970

(±)-Thalidomide

Selective inhibitor of TNF-α biosynthesis.

• Synonyme(s) : (±)-Thalidomide, (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• Formule empirique (notation de Hill): C₁₃H₁₀N₂O₄
• Numéro CAS: 50-35-1
• Poids moléculaire : 258.23
• Numéro MDL: MFCD00153873
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: DMSO: 25 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 10-30°C
• InChI: 1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
• Clé InChI: UEJJHQNACJXSKW-UHFFFAOYSA-N

Description

Description générale

Selective inhibitor of TNFα biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.

Selective inhibitor of TNF-α biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
TNF-α biosynthesis

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Reconstitution

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Gershon, D. 1995. Nat. Med.1, 1230.
Thompson, C. 1995. Lancet 346, 1289.
Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H312,H360D
• Conseils de prudence: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Classification des risques: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3