SML0374

U-104

≥98% (HPLC)

• Sinónimos: 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide, NSC 213841
• Fórmula empírica (notación de Hill): C₁₃H₁₂FN₃O₃S
• Número CAS: 178606-66-1
• Peso molecular: 309.32
• NACRES: NA.77
• PubChem Substance ID: 329825375
• UNSPSC Code: 12352200
• MDL number: MFCD00159265
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >15 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(F)C=C2
• InChI: 1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
• InChI key: YJQZNWPYLCNRLP-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

U-104 is a carbonic anhydrase IX (CAIX) inhibitor and a CAXII inhibitor.

U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable