SML0264

AEG 3482

≥98% (HPLC)

• Sinónimos: 6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
• Fórmula empírica (notación de Hill): C₁₀H₈N₄O₂S₂
• Número CAS: 63735-71-7
• Peso molecular: 280.33
• NACRES: NA.77
• PubChem Substance ID: 329825272
• UNSPSC Code: 12352200
• MDL number: MFCD02064987
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: faintly yellow to dark yellow
• solubility: DMSO: ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3
• InChI: 1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)
• InChI key: MQUYTXDAVCOCMX-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.

AEG3284 is an indirect inhibitor of JNK activity; HSP90 binder.

AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable