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SML0136

Sigma-Aldrich

TGN-020

≥98% (HPLC)

Sinónimos:

2-(Nicotinamide)-1,3,4-thiadiazole, N-(1,3,4-Thiadiazol-2-yl)-3-pyridinecarboxamide, N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide, N-(1,3,4-Thiadiazolyl)-m-nicotinamide

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5 MG
136,00 €
25 MG
539,00 €

136,00 €

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136,00 €
25 MG
539,00 €

About This Item

Fórmula empírica (notación de Hill):
C8H6N4OS
Número de CAS:
51987-99-6
Peso molecular:
206.22
Número MDL:
MFCD00708771
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329825185
NACRES:
NA.77

136,00 €

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Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to tan

solubilidad

DMSO: ≥8 mg/mL

temp. de almacenamiento

room temp

cadena SMILES

O=C(Nc1nncs1)c2cccnc2

InChI

1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)

Clave InChI

AGEGZHOPKZFKBP-UHFFFAOYSA-N

Categorías relacionadas

Aplicación

Beas2B human lung epithelial cells were treated with TGN-020 to study the effect on cigarette smoke extracts-induced CCN1 secretion.[1]

Acciones bioquímicas o fisiológicas

Aquaporin 4 (AQP4) inhibitor
TGN-020 is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000442631
0000442628
0000442628
0000442631
0000405923

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Jian Li et al.
Brain research bulletin, 170, 162-173 (2021-02-17)
The extracellular signal-regulated kinase (ERK) pathway has been reported to play a pivotal role in mediating spinal cord injury (SCI) progression. The present study aimed to investigate the effects of phosphorylated ERK1/2 (p-ERK1/2) inhibition on SCI-induced astrocyte activation and inflammation
Hiromu Monai et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(22), 11010-11019 (2019-05-18)
Spontaneous waves of cortical spreading depolarization (CSD) are induced in the setting of acute focal ischemia. CSD is linked to a sharp increase of extracellular K+ that induces a long-lasting suppression of neural activity. Furthermore, CSD induces secondary irreversible damage
Hyung-Geun Moon et al.
PloS one, 8(7), e68199-e68199 (2013-07-23)
Inflammation involves in many cigarette smoke (CS) related diseases including the chronic obstructive pulmonary disease (COPD). Lung epithelial cell released IL-8 plays a crucial role in CS induced lung inflammation. CS and cigarette smoke extracts (CSE) both induce IL-8 secretion
Dervis Dasdelen et al.
Mini reviews in medicinal chemistry, 20(6), 498-512 (2019-10-28)
In the literature screening, aquaporins were found in the cerebral structures including the pia mater, choroid plexus, ependyma, piriform cortex, hippocampus, dorsal thalamus, supraoptic and suprachiasmatic nuclei, white matter and subcortical organ. Among these, the most common are AQP1, AQP4
Cheng Guo et al.
Inflammation, 42(4), 1401-1412 (2019-04-05)
Acute lung injury (ALI) is a syndrome characterized by damage to the alveolar-capillary wall, pulmonary edema and recruitment of inflammatory cells. Previous studies have indicated that aquaporin 4 (AQP4) plays a key role in brain edema formation and resolution. However
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Preguntas

  1. We purchased a quantity of TGN-020 earlier this year but have had exceptional difficulty finding an effective solvent for this compound (tried DCM and H2O). Does Sigma-Aldrich have data on compatible solvents? Primary lit hasn't been helpful. Thanks!

    1 respuesta

    1. The solubility specification for this product is >/= 8mg/mL in DMSO. The rate may be higher and is lot-specific, however, the minimum concentration in DMSO is 8 mg/mL. A brief literature search shows that HCl, Ethanol, and Dimethylformamide have also been used to dissolve this compound.
      Please see the sample Certificate of Analysis for example:
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/SML0136-5MG0000258843.pdf

      If solubility issues continue, we kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, and click on "Report Product Issues" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.

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