SML0036

Procarbazine hydrochloride

≥98% (HPLC)

• Sinónimos: N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride
• Fórmula empírica (notación de Hill): C₁₂H₁₉N₃O·HCl
• Número de CAS: 366-70-1
• Peso molecular: 257.76
• Número CE: 206-678-6
• Número MDL: MFCD00072082
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825106
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to tan
• solubilidad: DMSO: ≥18 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.CNNCc1ccc(cc1)C(=O)NC(C)C
• InChI: 1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
• Clave InChI: DERJYEZSLHIUKF-UHFFFAOYSA-N

Descripción

Aplicación

Procarbazine hydrochloride has been used to study its physicochemical property.[1]

Procarbazine, an antineoplastic alkylating agent, may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an anticancer agent. It may be used to study new combination of anticancer drugs.

Acciones bioquímicas o fisiológicas

Procarbazine hydrochloride is a Antineoplastic alkylating agent

Procarbazine is an antineoplastic alkylating agent widely used in cancer chemotherapy in combination with other compounds. It has multiple mechanisms of action. Procarbazine inhibits protein, RNA and DNA synthesis in addition to being an alkylating agent.

Procarbazine is metabolized to azoprocarbazine either by cytochrome P450 enzyme and monoamine oxidase in an NADPH (nicotinamide adenine diphosphate) dependent or independent manner. It is considered neurotoxic.[2] Procarbazine is used in combination with therapy for treating Hodgkin′s disease.[3]

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302,H341,H350,H360
• Consejos de prudencia: P201 - P301 + P312 + P330 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1A
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable