The serum- and glucocorticoid-regulated kinase (Sgk1) is a member of the AGC kinase family. It is located on human chromosome 6q23.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human SGK around the phosphorylation site of Ser422.
Immunogen Range: 381-430
Acciones bioquímicas o fisiológicas
The serum- and glucocorticoid-regulated kinase (Sgk1) controls ENaC (expressed renal epithelial Na+ channel) by mineralocorticoids. SGK1 controls p27 phosphorylation upon the activation by mTOR-Raptor.
Características y beneficios
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Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation
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Molecular Cell, 30(6), 701-711 (2008)
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