SAB3500202

Anti-SIRPα antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: Anti-SHPS-1, Anti-SIRPa
• Número MDL: MFCD01634182
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: rat, mouse, human
• técnicas: immunocytochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Nº de acceso NCBI: NP_542970
• Nº de acceso UniProt: P78324
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... SIRPA(140885)

Descripción

Descripción general

Signal regulatory protein α (SIRPα) is expressed in dendritic cells and macrophages. It is a cell-surface protein. The protein possesses a highly glycosylated extracellular region, three immunoglobin superfamily domains and an intracellular domain with immunoreceptor tyrosine-based inhibitory motifs.[1][2] The gene encoding SIRPα is localized on human chromosome 20p13.[2]

Inmunógeno

SIRP alpha antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human SIRP alpha 1? The sequences of the immunogenic peptide differ from those of mouse, rat and bovine by one amino acid.

Acciones bioquímicas o fisiológicas

Signal regulatory protein α (SIRPα) acts as a modulator of immune responses.[1] It has a role in the migration, adhesion, growth and differentiation of cells. SIRPα associates with cluster of differentiation 47 (CD47) and prevents phagocytosis by macrophages.[3]

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3500202.

Forma física

Supplied in PBS with 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable