SIRPA
signal-regulatory protein alpha
Synonyms:
BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP
Species:
Human SIRPA (140885), Mouse Sirpa (19261), Rat Sirpa (25528), naked mole-rat Sirpa (101706086), dog SIRPA (609452), domestic cat SIRPA (101084787), Horse SIRPA (100067339), Domestic Rabbit SIRPA (100351485), sheep SIRPA (101105677), domestic guinea pig Sirpa (100719630) ...More
UniProtKB ID:
Gene ID:
- Human(140885) Summary: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
- Mouse(19261) signal-regulatory protein alpha
- Rat(25528) signal-regulatory protein alpha
- naked mole-rat(101706086) signal-regulatory protein alpha
- dog(609452) signal-regulatory protein alpha
- domestic cat(101084787) signal-regulatory protein alpha
- Horse(100067339) signal-regulatory protein alpha
- Domestic Rabbit(100351485) signal-regulatory protein alpha
- sheep(101105677) signal-regulatory protein alpha
- domestic guinea pig(100719630) signal-regulatory protein alpha
- cow(327666) signal-regulatory protein alpha
- chicken(419267) signal-regulatory protein alpha
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SIRPA Antibody, clone 3N8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Monoclonal Anti-CD172a/b antibody produced in mouse, clone SE5A5,
Species Reactivity
human
Application
flow cytometry
Anti-SIRP α1, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-PTPNS1, (C-terminal) antibody produced in mouse, clone 4C7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-SIRPA antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot