M2537

Mevastatin

≥98% (HPLC), powder or crystals

• Sinónimos: Compactin, ML-236B
• Fórmula empírica (notación de Hill): C₂₃H₃₄O₅
• Número de CAS: 73573-88-3
• Peso molecular: 390.51
• Beilstein: 1269441
• Número MDL: MFCD05662341
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278540
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: powder or crystals
• color: white to light yellow
• mp: 151 °C
• solubilidad: ethanol: 25-26 mg/mL, clear, colorless
• espectro de actividad antibiótica: neoplastics
• Modo de acción: enzyme | inhibits
• emisor: Daiichi-Sankyo
• temp. de almacenamiento: 2-8°C
• cadena SMILES: [H][C@]12[C@H](CCC=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)[C@@H](C)CC
• InChI: 1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
• Clave InChI: AJLFOPYRIVGYMJ-INTXDZFKSA-N
• Información sobre el gen: human ... HMGCL(3155) , HMGCR(3156) ; rat ... Hmgcr(25675)

Descripción

Descripción general

Chemical structure: statin

Mevastatin is a polyketide that belongs to the class of statins. It contains a hydroxy-hexahydronaphthalene ring.

Aplicación

Mevastatin has been used:

• to analyze its effects on chronic lymphocytic leukemia (CLL) cells by cytotoxic assay
• as a prenylation inhibitor to analyze its effects on human embryonic kidney (HEK) cells transfected with K-Ras
• as a statin agent to study its anti-cancer effect on human breast cancer cells and glioblastoma in vitro

Acciones bioquímicas o fisiológicas

Mevastatin is a selective inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme(A) reductase (HMG-CoA reductase), a major enzyme involved in cholesterol synthesis. It acts as a cholesterol-lowering agent. Mevastatin is obtained from various species of fungi. It acts as an antiresorptive agent and has therapeutic effects to treat osteoporosis. Mevastatin inhibits bone resorption by triggering osteoclast apoptosis. It is also involved in the inhibition of prenylation of proteins such as Ras. Mevastatin increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels by blocking the geranylgeranylation of transcription factor Rho.

Características y beneficios

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)