SML0005

Cerivastatin sodium salt hydrate

≥98% (HPLC)

• Sinónimos: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate, Rivastatin hydrate
• Fórmula empírica (notación de Hill): C₂₆H₃₃FNNaO₅ · xH₂O
• Número de CAS: 143201-11-0
• Peso molecular: 481.53 (anhydrous basis)
• Número MDL: MFCD20488047
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825082
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: powder
• actividad óptica: [α]/D +18 to +26° in ethanol
• condiciones de almacenamiento: desiccated
• color: white to tan
• solubilidad: H₂O: ≥5 mg/mL
• emisor: Bayer
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O.[Na+].COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c1-c2ccc(F)cc2)C(C)C
• InChI: 1S/C26H34FNO5.Na.H2O/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);;1H2/q;+1;/p-1/b11-10+;;/t19-,20-;;/m1../s1
• Clave InChI: NJHMEKXCHXHQPP-PZLZTSNUSA-M

Descripción

Descripción general

Cerivastatin sodium salt hydrate belongs to the statin class of lipid lowering agents. It helps in decreasing MAP kinase activation, blocking AP-1 (activator protein-1) and NF-kB (nuclear factor-kB ) binding activity, inhibiting inflammatory responses and ameliorated renal damage. It also lowers cholesterol. It is metabolized by cytochrome P450 (CYP)3A4 and (CYP)2C8. Cerivastatin sodium salt hydrate is linked to rhabdomyolysis.

Aplicación

Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.

Cerivastatin sodium salt hydrate may be used in cell signaling studies.

Acciones bioquímicas o fisiológicas

Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation. Cerivastatin suppresses the growth of macrophages and decreases the expression of matrix metalloproteinases and tissue factor molecules, thus reduces acute coronary events.

Cerivastatin sodium is an HMG-CoA reductase inhibitor. HMG-CoA is a key enzyme in the production of cholesterol.

Características y beneficios

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable