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Merck
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M1275

Sigma-Aldrich

Naproxen sodium

98.0-102.0%

Sinónimos:

(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt

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About This Item

Fórmula empírica (notación de Hill):
C14H13NaO3
Número de CAS:
26159-34-2
Peso molecular:
252.24
Número CE:
247-486-2
Número MDL:
MFCD00058507
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
57654352
NACRES:
NA.77

origen biológico

synthetic (organic)

Análisis

98.0-102.0%

formulario

powder

solubilidad

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

emisor

Bayer

cadena SMILES

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

Clave InChI

CDBRNDSHEYLDJV-FVGYRXGTSA-M

Información sobre el gen

human ... PTGS1(5742) , PTGS2(5743)

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Descripción general

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).

Aplicación

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin. It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.

Acciones bioquímicas o fisiológicas

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.
Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

Características y beneficios

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Aplicación

Referencia del producto
Descripción
Precios

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palabra de señalización

Danger

Frases de peligro

H302,H360

Clasificaciones de peligro

Acute Tox. 4 Oral - Repr. 1A

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Binding thermodynamics of Diclofenac and Naproxen with human and bovine serum albumins: A calorimetric and spectroscopic study
Bou-Abdallah F, et al.
The Journal of Chemical Thermodynamics, 103, 299-309 (2016)
Jing Xia et al.
Plant communications, 4(6), 100632-100632 (2023-05-31)
The phytohormone auxin plays central roles in many growth and developmental processes in plants. Development of chemical tools targeting the auxin pathway is useful for both plant biology and agriculture. Here we reveal that naproxen, a synthetic compound with anti-inflammatory
Flores Martín-Reyes et al.
Antioxidants (Basel, Switzerland), 12(12) (2023-12-23)
Inflammatory Bowel Diseases (IBD) are a group of chronic, inflammatory disorders of the gut. The incidence and activity of IBD are determined by both genetic and environmental factors. Among these factors, polymorphisms in genes related to autophagy and the consumption
Margarita Valero et al.
Langmuir : the ACS journal of surfaces and colloids, 26(13), 10561-10571 (2010-05-15)
The associative structures between F127 Pluronic micelles and four drugs, namely, lidocaine (LD), pentobarbital sodium salt (PB), sodium naproxen (NP), and sodium salicylate (SAL), were studied by small-angle neutron scattering (SANS). Different outcomes for the micellar aggregates are observed, which
Arın Gül Dal et al.
Journal of analytical methods in chemistry, 2014, 352698-352698 (2014-10-09)
Simple and rapid capillary zone electrophoretic method was developed and validated in this study for the determination of piroxicam in tablets. The separation of piroxicam was conducted in a fused-silica capillary by using 10 mM borate buffer (pH 9.0) containing 10%
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Chromatograms

application for HPLC

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