S8139

Sulindac

≥98.0%

• Sinónimos: (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
• Fórmula empírica (notación de Hill): C₂₀H₁₇FO₃S
• Número de CAS: 38194-50-2
• Peso molecular: 356.41
• Número CE: 253-819-2
• Número MDL: MFCD00599589
• Código UNSPSC: 12161501
• ID de la sustancia en PubChem: 57654635
• NACRES: NA.77

Propiedades

• origen biológico: synthetic (organic)
• Ensayo: ≥98.0%
• Formulario: powder
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• solubilidad: methanol: 50 mg/mL
• aplicaciones: forensics and toxicology; veterinary
• emisor: Merck & Co., Inc., Kenilworth, NJ, U.S.
• cadena SMILES: CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(C)=O
• InChI: 1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
• Clave InChI: MLKXDPUZXIRXEP-MFOYZWKCSA-N
• Información sobre el gen: human ... ALB(213) , PTGS1(5742) , PTGS2(5743)

Descripción

Aplicación

Treatment of human colorectal cancer cell lines induces MRP1 and MRP3 but not other members of the MRP family. Reported to significantly increase the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine. Sulindac was tested for its effect on heat-induced denaturation of albumin in vitro²⁸ and its ability to bind to human plasma protein.²⁹

Acciones bioquímicas o fisiológicas

Nonsteroidal anti-inflammatory; preferential inhibitor of COX-1.

Sulindac is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells^25,26 and reduces tumor burden in adenomatous polyposis patients.²⁷

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H317,H334,H361
• Consejos de prudencia: P201 - P280 - P301 + P310 + P330 - P302 + P352
• Clasificaciones de peligro: Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges