D6899

Diclofenac sodium salt

• Sinónimos: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
• Fórmula empírica (notación de Hill): C₁₄H₁₀Cl₂NNaO₂
• Número de CAS: 15307-79-6
• Peso molecular: 318.13
• Número CE: 239-346-4
• Número MDL: MFCD00082251
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277712
• NACRES: NA.77

Propiedades

• origen biológico: synthetic
• Análisis: ≥98% (TLC)
• formulario: powder
• mp: 283-285 °C
• solubilidad: methanol: 50 mg/mL, clear, colorless to faint yellow or tan
• emisor: Novartis
• temp. de almacenamiento: room temp
• cadena SMILES: [Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
• InChI: 1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
• Clave InChI: KPHWPUGNDIVLNH-UHFFFAOYSA-M
• Información sobre el gen: human ... PTGS1(5742) , PTGS2(5743)

Descripción

Aplicación

Diclofenac sodium has been used:

• to investigate its radioprotective potential in a study
• to determine the basic viscosity and hydrodynamic values of the solubilizers and their micellar adducts in a study
• as a standard for potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
• to inhibit phase II drug metabolizing enzyme (DME) in a study to investigate the inhibitory effects of an ethanol extract of Descurainia sophia seeds on Phase I and II DMEs

Acciones bioquímicas o fisiológicas

Diclofenac sodium salt is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a competitive and irreversible inhibitor of prostaglandin synthetase. Its analgesic and anti-inflammatory activities are based on the prevention of the synthesis of arachinodate metabolites via cyclooxygenase inhibition. It is found to hinder the conversion of arachidonic acid to prostaglandins, which mediate inflammatory process. The NSAIDs are found to inhibit both cyclooxygenase enzymes, COX-1 and COX-2, causing undesirable gastrointestinal effect. Diclofenac sodium also functions as a scavenger of free radicals and serves a radioprotective role in restoring supercoiled form of plasmid DNA damaged by radiation back to normal. Diclofenac sodium is oxidized by the donation of electron and transfer of hydrogen atom. It can be a potential radioprotective agent.

Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H301,H361d,H372,H411
• Consejos de prudencia: P202 - P260 - P264 - P273 - P280 - P301 + P310
• Clasificaciones de peligro: Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges