G2879

Glycine hydrochloride

≥99% (HPLC)

• Sinónimos: Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Fórmula lineal: H₂NCH₂CO₂H · HCl
• Número de CAS: 6000-43-7
• Peso molecular: 111.53
• Número CE: 227-841-8
• Número MDL: MFCD00012872
• Código UNSPSC: 12352209
• eCl@ss: 32160406
• ID de la sustancia en PubChem: 24895108
• NACRES: NA.32

Propiedades

• Análisis: ≥99% (HPLC)
• formulario: powder
• mol peso: 111.53
• condiciones de almacenamiento: (Tightly closed Dry)
• concentración: ≤100%
• técnicas: immunohistochemistry: suitable
• mp: 176-180 °C (lit.)
• solubilidad: water: 0.5 g/mL, clear, colorless
• temp. de almacenamiento: room temp
• cadena SMILES: Cl.NCC(O)=O
• InChI: 1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H
• Clave InChI: IVLXQGJVBGMLRR-UHFFFAOYSA-N

Descripción

Descripción general

Research area: Neuroscience

Aplicación

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.

Glycine hydrochloride has been used:

• in the preparation of glycine-HCl buffer
• to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
• to regenerate the sensor to elute the bound C-reactive protein (CRP)

Acciones bioquímicas o fisiológicas

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.

Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Información de seguridad

• Pictogramas: GHS05
• Palabra de señalización: Danger
• Frases de peligro: H314
• Consejos de prudencia: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Clasificaciones de peligro: Eye Dam. 1 - Skin Corr. 1
• Código de clase de almacenamiento: 8A - Combustible corrosive hazardous materials
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)