The solubility of this produst is tested in water at 50 mg/mL The solubility in saline has not been tested, however rates are expected to be similar. The solution stability has not been determined. Other sources state that solutions are stable for up to 1 month when stored in aliquots at -20°C.
D1159
Dexamethasone 21-phosphate disodium salt
≥98%
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100 MG
114,00 €
500 MG
344,00 €
1 G
573,00 €
5 G
2300,00 €
114,00 €
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100 MG
114,00 €
500 MG
344,00 €
1 G
573,00 €
5 G
2300,00 €
About This Item
Fórmula empírica (notación de Hill):
C22H28FNa2O8P
Número de CAS:
Peso molecular:
516.40
Beilstein:
6473066
Número CE:
Número MDL:
Código UNSPSC:
51422340
ID de la sustancia en PubChem:
NACRES:
NA.25
114,00 €
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Ensayo
≥98%
Formulario
powder
impurezas
≤1% ethanol
color
white to off-white
temp. de almacenamiento
2-8°C
cadena SMILES
[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O
InChI
1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
Clave InChI
PLCQGRYPOISRTQ-FCJDYXGNSA-L
Información sobre el gen
human ... NR3C1(2908)
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Categorías relacionadas
Aplicación
Dexamethasone 21-phosphate disodium salt has been used:
- as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 (HSV-1) in the induced reactivation (IR) and spontaneous shedding (SS) rabbit models[1]
- as a receptor analog to study its effects on glucocorticoid receptor activation in suprachiasmatic nuclei (SCN)-lesioned mice[2]
- to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs[3]
Acciones bioquímicas o fisiológicas
Dexamethasone 21-phosphate (Dex 21-P) is a pro-drug[4] that can undergo dephosphorylation to form dexamethasone with the help of intra-erythrocyte enzymes.[5] It exhibits therapeutic effects against cystic fibrosis[4] and postoperative cataract.[6] Dex 21-P disodium salt is a synthetic adrenal corticosteroid and possesses anti-inflammatory activity.[6]
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Repr. 2
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
dust mask type N95 (US), Eyeshields, Gloves
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We planned to dissolve it into saline and use to to inject as prenatal stressor to Sprague-Dawley rats via IP way. What is the solubility? I want to dissolve 100µg and 200µg into 10ml of saline. After dissolving what is the shelf life of that solution?
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