T2379

Tubocurarine hydrochloride pentahydrate

≥97%, neuromuscular blocker

• Sinónimos: (+)-Tubocurarine hydrochloride
• Fórmula empírica (notación de Hill): C₃₇H₄₁ClN₂O₆ · HCl · 5H₂O
• Número CAS: 6989-98-6
• Peso molecular: 771.72
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900034
• NACRES: NA.77
• MDL number: MFCD00150157
• Assay: ≥97%

Propiedades

• Nombre del producto: Tubocurarine hydrochloride pentahydrate, ≥97%
• Quality Segment: 200
• assay: ≥97%
• solubility: H₂O: soluble 50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow, ethanol: soluble, methanol: soluble
• storage temp.: 2-8°C
• SMILES string: O.O.O.O.O.Cl.[Cl-].COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4
• InChI: 1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1
• InChI key: WMIZITXEJNQAQK-GGDSLZADSA-N
• Gene Information: human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

Descripción

Application

Tubocurarine hydrochloride pentahydrate has been used as a acetylcholinesterase inhibitor (Ach) inhibitor in myotubes, muscle and as neuromuscular junction blocker in zebra fish embryos.

Biochem/physiol Actions

Tubocurarine is a muscle relaxant and a nicotinic acetylcholine receptor antagonist. It can induce neuromuscular blocking.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Tubocurarine hydrochloride pentahydrate is soluble in water at 50 mg/ml (with heat as required) and yields a clear to slightly hazy, colorless to yellow solution. It is also soluble in methanol and ethanol.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 + P330 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges