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Merck
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C0412

Sigma-Aldrich

Concanavalin A from Canavalia ensiformis (Jack bean)

Type IV-S, lyophilized powder, γ-irradiated, BioReagent, suitable for cell culture

Sinónimos:

Con A

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About This Item

Número de CAS:
11028-71-0
Número CE:
234-258-2
Número MDL:
MFCD00071069
Código UNSPSC:
23151817
NACRES:
NA.32

Nivel de calidad

200

esterilidad

γ-irradiated

tpo

Type IV-S

Línea del producto

BioReagent

formulario

lyophilized powder

técnicas

cell culture | mammalian: suitable

impurezas

salt, essentially free

solubilidad

PBS: 5 mg/mL, slightly hazy
H2O: soluble, slightly hazy

temp. de almacenamiento

−20°C

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Aplicación

Concanavalin A from Canavalia ensiformis (jack bean) has been used:
  • to induce spleen blastogenesis
  • to generate ConA blast targets from B6 and lpr spleen cells
  • to stimulate splenic lymphocytes from estrogen-and placebo-treated mice

Acciones bioquímicas o fisiológicas

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Nota de análisis

Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H317,H334,H361

Clasificaciones de peligro

Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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