A6185

Calpain Inhibitor I

≥97% (TLC), powder

• Sinónimos: ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Norleu-al
• Fórmula empírica (notación de Hill): C₂₀H₃₇N₃O₄
• Número de CAS: 110044-82-1
• Peso molecular: 383.53
• Beilstein: 7656053
• Número MDL: MFCD00065505
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24891066
• NACRES: NA.77

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Ensayo: ≥97% (TLC)
• Formulario: powder
• color: white
• solubilidad: DMSO: soluble; ethanol: soluble
• temp. de almacenamiento: −20°C
• cadena SMILES: [H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
• InChI: 1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
• Clave InChI: FMYKJLXRRQTBOR-BZSNNMDCSA-N
• Información sobre el gen: human ... CAPN1(823) , CTSB(1508) , PSMA1(5682)

Descripción

Aplicación

Calpain Inhibitor I have been used:

• as a component of protease inhibitor cocktail for gel shift analysis[1]
• for treating HeLa cell cultures[2]
• for inhibition of 26 S proteasome in 26 S proteasome inhibition assays[3]

Acciones bioquímicas o fisiológicas

Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis.[4] It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL..[5]

Can initiate apoptosis in HL-60 cells[6] but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes.[7] Inhibits cyclin B degradation and arrests the cell cycle at G₁/S and at meta-/anaphase.[8] Blocks induction of nitric oxide synthase by LPS in macrophages.[9]

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)