282200

Galangin

autophagy inducing flavonoid

• Sinónimos: 3,5,7-Trihydroxyflavone, Norizalpinin
• Fórmula empírica (notación de Hill): C₁₅H₁₀O₅
• Número de CAS: 548-83-4
• Peso molecular: 270.24
• Beilstein: 272179
• Número CE: 208-960-4
• Número MDL: MFCD00006833
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 57648294
• NACRES: NA.79

Propiedades

• Ensayo: ≥95% (HPLC)
• Formulario: powder
• color: yellow
• mp: 214-215 °C (lit.)
• cadena SMILES: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
• Clave InChI: VCCRNZQBSJXYJD-UHFFFAOYSA-N
• Información sobre el gen: human ... ADORA2A(135) , ADORA3(140) , CYP1A2(1544) ; rat ... Adora1(29290) , Adora2a(25369)

Descripción

Descripción general

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.[1]

Aplicación

Galangin has been used:

• as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity[1]
• to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes[2]
• as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy[3]

Acciones bioquímicas o fisiológicas

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory[1] and anti-obesity properties.[4] In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis.[5] Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.[6]

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves