01810

Cycloheximide

≥90% (HPLC)

• Sinónimos: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Fórmula empírica (notación de Hill): C₁₅H₂₃NO₄
• Número de CAS: 66-81-9
• Peso molecular: 281.35
• Beilstein: 88868
• Número CE: 200-636-0
• Número MDL: MFCD00082346
• Código UNSPSC: 51102829
• ID de la sustancia en PubChem: 329747360
• NACRES: NA.85

Propiedades

• origen biológico: microbial
• Nivel de calidad: 200
• Ensayo: ≥90% (HPLC)
• Formulario: powder or crystals
• color: white to light beige
• espectro de actividad antibiótica: fungi; yeast
• Modo de acción: protein synthesis | interferes
• cadena SMILES: N1C(=O)CC(CC1=O)C[C@@H](O)[C@@H]2C[C@H](C[C@@H](C2=O)C)C
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• Clave InChI: YPHMISFOHDHNIV-FSZOTQKASA-N
• Información sobre el gen: human ... FKBP1A(2280) , PIN1(5300)

Descripción

Aplicación

Cyclohexamide (CHX) is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins, super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques, activate cumulus-free equine oocytes, and to have neuroprotective properties.

Acciones bioquímicas o fisiológicas

Cyclohexamide inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome.

Cycloheximide (CHX) is an antibiotic produced by Strptomyces sp.. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Envase

1G, 5G

Otras notas

Conditions for safe storage, including any incompatibilities. Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H300,H341,H360D,H411
• Consejos de prudencia: P202 - P264 - P273 - P280 - P301 + P310 - P391
• Clasificaciones de peligro: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges