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582231

Sigma-Aldrich

Tetanus Toxoid

from Clostridium tetani, , lyophilized, nontoxic antigenic agent, Calbiochem®

Sinónimos:

TTx

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

Tetanus Toxoid, Clostridium tetani, This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD₅₀ in mice.

Nivel de calidad

200

Formulario

lyophilized

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

Descripción general

Tetanus Toxoid belongs to the vaccine class of medications. Useful for immunization against tetanus and wound prophylaxis. Non-toxic as determined by an LD50 assay in mice.

Aplicación

Tetanus Toxoid, Clostridium tetani has been used: as a positive-control antigen used to assess antibodies against different SARS-CoV-2 proteins and peptides in patients[1]; to assess lymphocyte proliferation in rabbit PBMC cultures in response to recall antigen stimulation[2]; a stimulus for PBMCs from chronic HBV carrier donors in a T cell proliferation assay[3]

Acciones bioquímicas o fisiológicas

Tetanus Toxoid acts against Clostridium tetani, a gram-positive bacillus that produces a neurotoxin called tetanospasmin. Tetanospasmin prevents the release of an inhibitory neurotransmitter and causes unopposed muscle contractions and spasms. Tetanus toxoid vaccine stimulates the immune system to respond to the vaccine’s antigens. The immune system’s T-lymphocytes (TH2 and B cells) secrete immunoglobulin against the antigen in the vaccine. This immunoglobulin helps to protect against future infections.

Características y beneficios

  • Prepared by formaldehyde inactivation of tetanus toxin.
  • Prepared by formaldehyde inactivation of tetanus toxin.
  • Toxoid retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.
  • Cell permeable: no
  • Product does not compete with ATP.
  • Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Forma física

Lyophilized from 100 mM histidine, 100 mM NaCl, 5% trehalose, pH 7.0.

Reconstitución

Reconstitute in 50 µl of sterile distilled H₂O

Otras notas

Wrenger, S., et al. 2000. J. Biol. Chem.275, 22180.
Habermann E. and Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.) Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Allan Ma et al.
Human vaccines & immunotherapeutics, 16(4), 756-778 (2019-11-07)
In chronic Hepatitis B Virus (HBV) infections HBV-specific T cells are functionally impaired. Immunotherapy may restore HBV-specific T cell responses essential for sustained disease remission off-treatment and induction of a functional cure. Chimigen® Molecules are fusion proteins of antigen(s) with

Preguntas

  1. Would you kindly provide the product specifications in particular the concentration of the Tetanus Toxoid, Clostridium tetani.

    1 respuesta

    1. This product is lyophilized from a solution containing 25 ug Tetanus toxoid in 100 mM histidine, 100 mM NaCl, and 5% trehalose. When reconstituted to the recommended 50 uL volume, the concentration of toxin will be 0.5 ug/ul. Additional details are available in the lot specific Certificate of Analysis. Please see the link below to access these Certificates:
      https://www.emdmillipore.com/product/Tetanus-Toxoid-Clostridium-tetani-Calbiochem,EMD_BIO-582231#anchor_COA

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