557403
RNA Polymerase III Inhibitor
RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).
Sinónimos:
RNA Polymerase III Inhibitor, ML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide
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About This Item
Fórmula empírica (notación de Hill):
C19H15Cl2N3O2S2
Número de CAS:
Peso molecular:
452.38
Código UNSPSC:
12352200
NACRES:
NA.54
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Nivel de calidad
Análisis
≥95% (HPLC)
formulario
solid
fabricante / nombre comercial
Calbiochem®
condiciones de almacenamiento
OK to freeze
protect from light
color
off-white
solubilidad
DMSO: 15 mg/mL
Condiciones de envío
ambient
temp. de almacenamiento
2-8°C
InChI
1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3
Clave InChI
BVBDTTLISMIOJY-UHFFFAOYSA-N
Descripción general
A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).
A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription.
Acciones bioquímicas o fisiológicas
Cell permeable: yes
Primary Target
activity against RNA Polymerase III
activity against RNA Polymerase III
Product does not compete with ATP.
Reversible: no
Target IC50: 27 and 32 µM for Human and S. cerevisiae RNA Pol III
Envase
Packaged under inert gas
Advertencia
Toxicity: Carcinogenic / Teratogenic (D)
Nota de preparación
Slight warming may be necessary to achieve complete solubilization.
Reconstitución
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Otras notas
Wu, L., et al. 2003. Euk. Cell2, 256.
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
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