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400046

Sigma-Aldrich

Hydroxyurea

≥98% (HPLC), solid, RNR inhibitor, Calbiochem

Sinónimos:

Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I

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About This Item

Fórmula empírica (notación de Hill):
CH4N2O2
Número de CAS:
127-07-1
Peso molecular:
76.05
Número MDL:
MFCD00007943
Código UNSPSC:
12352200
NACRES:
NA.77

product name

Hydroxyurea, Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

Nivel de calidad

100

Análisis

≥98% (HPLC)

formulario

solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze

color

white

solubilidad

water: 5 mg/mL

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

InChI

1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

Clave InChI

VSNHCAURESNICA-UHFFFAOYSA-N

Descripción general

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.

Acciones bioquímicas o fisiológicas

Cell permeable: no
Primary Target
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no

Advertencia

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitución

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.

Otras notas

Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H340,H361

Clasificaciones de peligro

Muta. 1B - Repr. 2

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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