1332000

Hydroxyurea

United States Pharmacopeia (USP) Reference Standard

• Sinónimos: Hydroxycarbamide
• Fórmula lineal: NH₂CONHOH
• Número CAS: 127-07-1
• Peso molecular: 76.05
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750138
• MDL number: MFCD00007943
• Beilstein/REAXYS Number: 1741548

Propiedades

• grade: pharmaceutical primary standard
• agency: USP
• API family: hydroxyurea
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: NC(=O)NO
• InChI: 1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
• InChI key: VSNHCAURESNICA-UHFFFAOYSA-N
• Gene Information: human ... RRM1(6240), RRM2(6241), RRM2B(50484)

Descripción

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Información de seguridad

• pictograms: GHS08
• signalword: Danger
• hcodes: H340,H361
• pcodes: P201 - P280 - P308 + P313
• Hazard Classifications: Muta. 1B - Repr. 2
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable