M9948

Mirin

≥98% (HPLC), powder

• Sinónimos: 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one
• Fórmula empírica (notación de Hill): C₁₀H₈N₂O₂S
• Número de CAS: 299953-00-7
• Peso molecular: 220.25
• Número MDL: MFCD05885480
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329818100
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• condiciones de almacenamiento: desiccated
• color: red to orange
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2
• InChI: 1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-
• Clave InChI: YBHQCJILTOVLHD-YVMONPNESA-N
• Información sobre el gen: human ... MRE11A(4361)

Descripción

Aplicación

Mirin has been used:

• as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
• as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
• in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)

Acciones bioquímicas o fisiológicas

Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP.

Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable