GST fusion protein corresponding to residues 554-702 of human TBX2
Aplicación
Detect TBX2 also known as T-box 2 with Anti-TBX2 Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in IP & WB.
Calidad
routinely evaluated by immunoblot on RIPA lysates from MCF-7 human breast adenocarcinoma cells
Descripción de destino
74kDa
Forma física
antiserum with 0.05% sodium azide before the addition of glycerol to 30%
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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To identify new immortalizing genes with potential roles in tumorigenesis, we performed a genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts deficient for the oncogene Bmi1. We identified the T-box member TBX2 as a
Tbx2 encodes a transcriptional repressor implicated in the development of numerous organs in mouse. During lung development TBX2 maintains the proliferation of mesenchymal progenitors, and hence, epithelial proliferation and branching morphogenesis. The pro-proliferative function was traced to direct repression of
Development (Cambridge, England), 132(10), 2475-2487 (2005-04-22)
Mutations in T-box genes are the cause of several congenital diseases and are implicated in cancer. Tbx20-null mice exhibit severely hypoplastic hearts and express Tbx2, which is normally restricted to outflow tract and atrioventricular canal, throughout the heart. Tbx20 mutant
In the embryonic mammalian lung, mesenchymal cells act both as a signaling center for epithelial proliferation, differentiation and morphogenesis as well as a source for a multitude of differentiated cell types that support the structure of the developing and mature
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