QBD10009

Biotin-dPEG^®₄-TFP ester

• Sinónimos: Polyethylene glycol
• Fórmula empírica (notación de Hill): C₂₇H₃₇F₄N₃O₈S
• Peso molecular: 639.66
• Código UNSPSC: 12352108
• ID de la sustancia en PubChem: 329823873
• NACRES: NA.22

Propiedades

• Ensayo: >90%
• Formulario: solid or viscous liquid
• idoneidad de la reacción: reaction type: Biotinylations; reaction type: Biotinylations; reactivity: amine reactive; reagent type: cross-linking reagent
• arquitectura del polímero: shape: linear; functionality: monofunctional
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C(CCCCC1SCC(N2)C1NC2=O)NCCOCCOCCOCCOCCC(OC3=C(C(F)=CC(F)=C3F)F)=O
• Clave InChI: XBGOXOZYGAXNFP-UHFFFAOYSA-N

Descripción

Aplicación

Biotin-dPEG^®₄-TFP ester is an amphiphilic and hydrolytically stable compound used as a cross-linking reagent in biotinylations reactions.[1]

Características y beneficios

Biotin-dPEG^®₄-TFP ester has 2,3,5,6-tetrafluorophenyl (TFP) moiety which hydrolyzes more slowly than NHS ester in aqueous media and are more reactive towards amines than NHS esters. The single molecular weight Biotin-dPEG^®₄-TFP ester has a long spacer of precise length (19.2 Å) between the biotin moiety and the labeled molecule. This dPEG spacer imparts a high degree of water solubility to the biotin label. The PEG spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Información legal

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable