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Merck

D0710000

Dexamethasone 21-acetate

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Dexamethasone 21-acetate, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate

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About This Item

Fórmula empírica (notación de Hill):
C24H31FO6
Número de CAS:
Peso molecular:
434.50
Beilstein:
2342608
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

origen biológico

synthetic

grado

pharmaceutical primary standard

Agency

EP

familia API

dexamethasone

envase

pkg of 150 mg

fabricante / nombre comercial

EDQM

condiciones de almacenamiento

protect from light

color

white

solubilidad

water: <0.1 g/L

aplicaciones

pharmaceutical (small molecule)

Formato

neat

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

cadena SMILES

[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O

InChI

1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1

Clave InChI

AKUJBENLRBOFTD-RPRRAYFGSA-N

Información sobre el gen

human ... NR3C1(2908)

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Descripción general

Dexamethasone acetate (Decadron-LA) belongs to the class of long-acting glucocorticoids, commonly used as a pharmaceutical ingredient in creams, ointments, microemulsions, lotions, aerosols, etc.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Dexamethasone acetate is used as an EP reference standard to quantify the analyte in pharmaceutical formulations using chromatography ttechniques.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto
Descripción
Precios

Pictogramas

Health hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3


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Dexamethasone acetate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 10(3), 4963-4965 (2021)
Textbook of Veterinary Internal Medicine, 87-92 (2009)
Qing-yu Xiang et al.
Archives of pharmacal research, 30(4), 519-525 (2007-05-11)
The objective of the present study was to develop a novel solid lipid nanoparticle (SLN) for the lung-targeting delivery of dexamethasone acetate (DXM) by intravenous administration. DXM loaded SLN colloidal suspensions were prepared by the high pressure homogenization method. The
Carolina Gómez-Gaete et al.
Journal of controlled release : official journal of the Controlled Release Society, 128(1), 41-49 (2008-04-01)
We have combined the therapeutic potential of nanoparticles systems with the ease of manipulation of microparticles by developing a hybrid vector named Trojan particles. We aim to use this new delivery vehicle for intravitreal administration of dexamethasone. Initialy, dexamethasone acetate
Zhao-xiong Zhou et al.
Acta pharmacologica Sinica, 30(11), 1577-1584 (2009-11-06)
To investigate the in vitro release profile of drugs encapsulated within perfluorocarbon (PFC) nanoparticles (NPs) and their ability to inhibit the activity of vascular smooth muscle cells (SMCs). Dexamethasone phosphate (DxP) or dexamethasone acetate (DxA) was encapsulated into PFC nanoparticles

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