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D4902

Dexametasona

powder, BioReagent, suitable for cell culture, ≥97%

Dexamethasone

Sinónimos:

(11β,16α)-9-Fluoro-11,17,21-trihidroxi-16-metilpregna-1,4-dieno-3,20-diona, 9α-Fluoro-16α-metil-11β,17α,21-trihidroxi-1,4-pregnadieno-3,20-diona, 9α-fluoro-16α-metilprednisolona, Prednisolona F

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Fórmula empírica (notación de Hill):
C22H29FO5
Número CAS:
50-02-2
Peso molecular:
392.46
UNSPSC Code:
12352209
NACRES:
NA.75
PubChem Substance ID:
24893906
EC Number:
200-003-9
Beilstein/REAXYS Number:
2066651
MDL number:
MFCD00064136
Biological source:
synthetic
Form:
powder
Assay:
≥97%
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Servicio técnico
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biological source

synthetic

Quality Level

200

product line

BioReagent

assay

≥97%

form

powder

potency

4-500 ng/mL

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

mp

262-264 °C (lit.)

solubility

methanol: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Application

La dexametasona se utiliza para estudiar la apoptosis, las vías de comunicación celular, la diferenciación celular[1] y la expresión génica.

Biochem/physiol Actions

Glucocorticoide antiinflamatorio
Glucocorticoide antiinflamatorio. Regula la supervivencia, el crecimiento y la diferenciación de las células T. Inhibe la inducción de la óxido nítrico sintasa.
Es poco metabolizada en el organismo y tiene gran afinidad y biodisponibilidad.

Packaging

Frasco de vidrio sin fondo. El contenido está en el interior del cono fundido insertado.

Physical form

polvo 2-8 °C; reserva-congelada en alícuotas de trabajo, evite congelaciones y descongelaciones repetidas

Preparation Note

Para preparar una disolución de reserva de 20 μ/ml, añada 1 ml de etanol absoluto por miligramo de producto; agite suavemente hasta que se disuelva. Vaya añadiendo 49 ml de medio estéril por ml de etanol añadido, mientras se mezcla, para alcanzar una concentración final de 20 μ/ml.

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Este artículo
D8893D1756D9184
Dexamethasone powder, BioReagent, suitable for cell culture, ≥97%

Sigma-Aldrich

D4902

Dexamethasone

Dexamethasone powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

Sigma-Aldrich

D8893

Dexamethasone

Dexamethasone ≥98% (HPLC), powder

Sigma-Aldrich

D1756

Dexamethasone

Dexamethasone meets USP testing specifications

Sigma-Aldrich

D9184

Dexamethasone

biological source

synthetic

biological source

synthetic (organic)

biological source

-

biological source

synthetic (organic)

assay

≥97%

assay

≥80% (HPLC)

assay

≥98% (HPLC)

assay

97.0-102.0%

product line

BioReagent

product line

BioXtra

product line

-

product line

-

form

powder

form

powder

form

powder

form

solid

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCP4649
BCCP1648
WXBF5978V
WXBF5148V
WXBF3689V

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Número de artículo de comercio global

SKUGTIN
D4902-25MG04061835514076
D4902-1G04061835507238
D4902-100MG04061835514069
D4902-500MG04061835514083
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Questions

1–10 of 20 Questions  

  1. Dear Customer support, Is this product  Dexamethasone, cat #D4902  suitable for in vivo use (mice treatment)?

    1 answer

    1. While we do not conduct in-house testing on these DMSO products in animals, there are numerous research papers available online documenting the utilization of this compound in animal studies. These papers serve as valuable resources for understanding the compound's effects and potential applications in various animal models:

      eNeuro. 2016 Mar-Apr; 3(2): ENEURO.0133-15.2016.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819286/
      Mice were injected with carprofen (5 mg/kg, s.c.; catalog #024751, Butler Schein Animal Health) and dexamethasone (40 mg/kg, i.m.; catalog #D4902, Sigma-Aldrich) prior to surgery.

      https://www.google.com/search?q=D4902+mg%2Fkg+mice&rlz=1C1GCEA_enUS976US976&oq=D4902+mg%2Fkg+mice&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIHCAEQIRigATIHCAIQIRigATIHCAMQIRigATIHCAQQIRigATIHCAUQIRigAdIBCDg3ODJqMGo3qAIAsAIA&sourceid=chrome&ie=UTF-8&sei=VudraPqaJO6t5NoPvZyokQw

      Helpful?

  2. Two questions: 1. How to store 1mg/ml solution and how stable? 2. Is it advisable to filter working solution 20ug/ml with 0.22 um prior to use?

    1 answer

    1. This product is stable for approximately 5 years in powder form with the vial unopened. It is guaranteed for 1 year from the date of shipment. The stability upon reconstitution has not been determined. However, for a similar product, it is recommended to aliquot and freeze at -20°C after reconstitution. Stock solutions are stable for up to 2 months at -20°C and should be protected from light. Degradation occurs gradually and depends on exposure frequency and intensity. Discolored, cloudy, or particulate-containing solutions should be discarded. Solutions can be sterile filtered using a 0.22 µm membrane, as the powders are not sterile.

      Helpful?

  3. Hello,  I prepared a solution of Dexamethasone in DMSO and PBS for IP injection in mice for 20 days daily. Is it okay to store the solution at 4°C?

    1 answer

    1. Dexamethasone solutions in DMSO are stable for at least 30 days when stored at 4 °C and protected from light. Do not dilute to working concentrations in an aqueous buffer or medium until ready to use.

      Helpful?

  4. Can I store D4902 at -80°C? If I store it at -80°C instead of -20°C, can I use it stably for more than 2 months?

    1 answer

    1. Long-term solution stability studies have not been performed on this material. The impact of stability at -80°C has not been determined. However, an analytical standard available at 1 mg/mL in methanol, as product D-085, has a shelf life of 4 years when stored at -20°C. In addition, therapeutic preparations of Dexamethasone 3.3 mg/mL for injection manufactured by Hospira, list a shelf life of 24 months at -20°C. This product, in solution, may demonstrate similar stability.

      Helpful?

  5. What is the solubility of D4902 (Dexamethasone) in DMSO and ethanol? Additionally, how should stock solutions be stored?

    1 answer

    1. The solubility of D4902 (Dexamethasone) in ethanol is 25 mg/ml and DMSO is 25 mg/ml. Dexamethasone is insoluble in water. Stock solutions are stable for up to 2 months at -20°C.

      Helpful?

  6. IF Dexamethasone solutions forgrt to protected from light, what will happen in these solutions?

    1 answer

    1. Prepared solutions of Dexamethasone should be protected from light. Degradation occurs gradually and is dependent on the frequency and intensity of exposure. Solutions that appear discolored, cloudy, or contain particulates should be discarded. Unfortunately, there is not way to determine the degree of decomposition.

      Helpful?

  7. I read that the dexamethasone is packaged in a bottomless glass bottle, in an inserted fused cone. Is this cone sealed with a rubber lid to be able to safely open the bottle and dissolve all contents before fully opening the bottle?

    1 answer

    1. Please see the attached images of the vial and cap used to package this product. The cap is a screw-type and does not include a septum. Threading secures the inner cone to the outer vial.

      Helpful?

  8. what are different between D4902 and D1756? and if the same the both, why D4902 is descriptive about 'suitable for cell culture'?

    1 answer

    1. Product D4902 and D1756 are identical compounds, but are tested differently. Product D4902 is tested specifically for suitability in cell culture applications, while the D1756 has a slightly higher minimum purity specification. Please see the sample Certificate of Analysis to view the testing and specifications for each product:

      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/D1756-BULKBCCK0031.pdf
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/D4902-BULKBCCJ0003.pdf

      Helpful?

  9. Are there any references for D2915?

    1 answer

    1. Please check the following offerings for Certified Reference standards for Dexamethasone:

      https://www.sigmaaldrich.com/product/sial/d0700000
      https://www.sigmaaldrich.com/product/sial/phr1526
      https://www.sigmaaldrich.com/product/usp/1176007

      Helpful?

  10. Can I use Product D4902 as a local application (after preparation) to induce osteogenesis in a human clinical trial?

    1 answer

    1. This product is suitable for cell culture application and is intended for research use only. For more information on "Use of Products", please consult our Terms and Conditions https://www.sigmaaldrich.com/US/en/life-science/legal/terms-and-conditions#3

      Helpful?

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