P3075

Phenylarsine oxide

≥97%, powder

• Synonyme(s) : Arzene, Oxophenylarsine, PAO
• Formule empirique (notation de Hill): C₆H₅AsO
• Numéro CAS: 637-03-6
• Poids moléculaire : 168.02
• Numéro Beilstein : 2935227
• Numéro CE : 211-275-3
• Numéro MDL: MFCD00001990
• Code UNSPSC : 12352119
• ID de substance PubChem : 24898387
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 100
• Pureté: ≥97%
• Forme: powder
• Couleur: white to off-white
• Pf: 145-148 °C
• Solubilité: DMSO: 50 mg/mL
• Chaîne SMILES: O=[As]c1ccccc1
• InChI: 1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
• Clé InChI: BQVCCPGCDUSGOE-UHFFFAOYSA-N

Description

Description générale

Phenylarsine oxide (PhAsO⁴) is a bifunctional SH group chemical. It is hydrophobic in nature.

Application

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).

Actions biochimiques/physiologiques

Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Caractéristiques et avantages

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H301 + H331,H410
• Conseils de prudence: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable