487928

Nocodazole

≥99% (HPLC), solid, microtuble inhibitor, Calbiochem

• Synonyme(s) : Nocodazole, R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
• Formule empirique (notation de Hill) : C₁₄H₁₁N₃O₃S
• Numéro CAS: 31430-18-9
• Poids moléculaire : 301.32
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00005588
• Assay: ≥99% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Propriétés

• Nom du produit: Nocodazole, Inhibitor of mitosis.
• Quality Segment: 100
• description: RTECS - DD6521000
• assay: ≥99% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: pale yellow
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [s]1c(ccc1)C(=O)c2cc3nc([nH]c3cc2)NC(=O)OC
• InChI: 1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
• InChI key: KYRVNWMVYQXFEU-UHFFFAOYSA-N

Description

General description

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Promotes tubulin depolymerization

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.

Other Notes

Park, H., et al. 2011. Chem. Med. Chem.in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Informations sur la sécurité

• pictograms: GHS08
• signalword: Warning
• hcodes: H341,H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 2 - Repr. 2
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable