N1638

Nystatin Suspension

suspension, non-animal origin, suitable for cell culture, BioReagent

• Synonyme(s) : Fungicidin, Mycostatin
• Numéro CAS: 1400-61-9
• Code UNSPSC : 12352207
• ID de substance PubChem : 24897511
• Nomenclature NACRES : NA.76

Propriétés

• product name: Nystatin Suspension, suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture
• Gamme de produits: BioReagent
• Niveau de qualité: 200
• Forme: suspension
• Concentration: 10,000 unit/mL in DPBS
• Technique(s): cell culture | mammalian: suitable
• Impuretés: endotoxin, tested
• Couleur: yellow
• Spectre d'activité de l'antibiotique: fungi; yeast
• Mode d’action: cell membrane | interferes
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\CC\C=C\C=C\[C@H](C)[C@@H](O)[C@@H]1C)O2)C(O)=O
• InChI: 1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• Clé InChI: VQOXZBDYSJBXMA-QEKUPDCNSA-N

Description

Description générale

Chemical structure: polyene

Application

Nystatin suspension has been used:

• to inhibit caveolin-mediated endocytosis
• as a component of Eagle′s minimum essential medium (EMEM)
• to enumerate lactic acid bacteria (LAB)
• in preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in toll-like receptor 2 (TLR2)-expressing THP1 cells.

This product is recommended for use in cell culture applications at 24 mL/L.

Actions biochimiques/physiologiques

Nystatin is a polyene, broad-spectrum antibiotic, which modifies the microstructure of lipid rafts. It can sequester cholesterol present on the cell membrane of eukaryotes. Nystatin regulates immune responses through cytokine signaling, lymphocyte activation and pathogen recognition.

Attention

This product is stable at 37°C for three days.

Notes préparatoires

It is 0.1μ filtered and cell culture tested.

Autres remarques

Nystatin suspension available in 20 mL and 100 mL pack size.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable