N9150

Nystatin

ready made solution, suitable for cell culture

• Synonyme(s) : Nystatin, Fungicidin, Mycostatin
• Numéro CAS: 1400-61-9
• Numéro MDL: MFCD25541651
• Code UNSPSC : 12352207
• Nomenclature NACRES : NA.76

Propriétés

• product name: Nystatin Ready made solution, suitable for cell culture
• Source biologique: Streptomyces noursei
• Forme: solution
• Technique(s): cell culture | mammalian: suitable
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: O[C@@H]([C@H](C)[C@H](C)O1)[C@@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](O)(O3)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC1=O
• InChI: 1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• Clé InChI: VQOXZBDYSJBXMA-QEKUPDCNSA-N

Description

Description générale

Nystatin is a fungistatic and fungicidal polyene antibiotic. It binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active against Candida species. However, it is also reported to be effective against Aspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin to Saccharomyces cerevisiae was reported to be 3μg/ml while for clinical isolates of Candida albicans the MIC was reported to be 4-16μg/ml.

Actions biochimiques/physiologiques

Mode of Action: Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels. It also functions as a lipid raft-inhibiting reagent and as membrane associated cholesterol.

Antimicrobial spectrum: Nystatin acts against fungi, yeasts and molds.

Caractéristiques et avantages

• Nystatin ready made solution is a fully solubilized formulation of Nystatin with potency of 8000-13000 units/ml according to USP standard.
• Nystatin ready made solution is 0.2μm filtered, endotoxin.
• The suggested working concentration of Nystatin ready made solution is 30 units/ml.
• The ready made solution is light sensitive. It is recommended to store the solution in the dark.
• It is recommended to avoid freeze thaw cycles of this product. Therefore, it is recommended to aliquot and store at -20°C.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable