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U1128

Sigma-Aldrich

Uracil

BioReagent, suitable for cell culture

Synonym(e):

2,4(1H,3H)-pyrimidindion, 2,4-Dihydroxypyrimidin, 2,4-Pyrimidinediol

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About This Item

Empirische Formel (Hill-System):
C4H4N2O2
CAS-Nummer:
66-22-8
Molekulargewicht:
112.09
Beilstein:
507828
EG-Nummer:
200-621-9
MDL-Nummer:
MFCD00006016
UNSPSC-Code:
12352207
PubChem Substanz-ID:
24900623
NACRES:
NA.75

Biologische Quelle

synthetic (organic)

Produktlinie

BioReagent

Assay

≥99% (HPLC)

Form

powder

Methode(n)

cell culture | mammalian: suitable

mp (Schmelzpunkt)

>300 °C (lit.)

Löslichkeit

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

Lagertemp.

room temp

SMILES String

O=C1NC=CC(=O)N1

InChI

1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

InChIKey

ISAKRJDGNUQOIC-UHFFFAOYSA-N

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Allgemeine Beschreibung

Uracil belongs to the pyrimidine nucleobase family. It is naturally occurring and is an important and active part of RNA.

Anwendung

Uracil has been used as a supplement in complete synthetic medium 1×, synthetic complete glucose-based yeast media (SC), and yeast extract with supplements (YES) media for culturing yeast cells.

Biochem./physiol. Wirkung

Uracil and its derivatives play an integral part in medicinal chemistry for the synthesis of cancer, viral infections, autosomal recessive disorder, thyroid, and diabetic drugs.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Deepthi Ramesh et al.
European journal of medicinal chemistry, 207, 112801-112801 (2020-09-15)
Uracil is one of the most notable pharmacophores in medicinal chemistry as the pyrimidine nucleobase forms an integral part of many commercial drugs. Though the name uracil is usually associated with cancer drugs, there are many uracil-based compounds which can
Brian T Wilhelm et al.
Nature protocols, 5(2), 255-266 (2010-02-06)
Next-generation sequencing technologies are revolutionizing genomics research. It is now possible to generate gigabase pairs of DNA sequence within a week without time-consuming cloning or massive infrastructure. This technology has recently been applied to the development of 'RNA-seq' techniques for
Sandra M Carvalho et al.
PloS one, 8(3), e58492-e58492 (2013-03-19)
Links between carbohydrate metabolism and virulence in Streptococcus pneumoniae have been recurrently established. To investigate these links further we developed a chemically defined medium (CDM) and standardized growth conditions that allowed for high growth yields of the related pneumococcal strains
Pietro Andreone et al.
Gastroenterology, 147(2), 359-365 (2014-05-14)
The interferon-free regimen of ABT-450 (a protease inhibitor), ritonavir, ombitasvir (an NS5A inhibitor), dasabuvir (a non-nucleoside polymerase inhibitor), and ribavirin has shown efficacy in patients with hepatitis C virus (HCV) genotype 1b infection-the most prevalent subgenotype worldwide. We evaluated whether
Jordan J Feld et al.
The New England journal of medicine, 370(17), 1594-1603 (2014-04-12)
The interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r) and the NS5A inhibitor ombitasvir (also known as ABT-267) plus the nonnucleoside polymerase inhibitor dasabuvir (also known as ABT-333) and ribavirin has shown efficacy against the hepatitis C virus
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