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T8944
Topoisomerase II α human
(Single band on SDS-PAGE), liquid
Synonym(e):
Topoisomerase II alpha, TOPO® II, p170
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Empfohlene Produkte
Qualitätsniveau
Form
liquid
Mol-Gew.
170 kDa
UniProt-Hinterlegungsnummer
Lagertemp.
−70°C
Angaben zum Gen
human ... TOP2A(7153)
Verwandte Kategorien
Allgemeine Beschreibung
Topoisomerase II α (TopoIIα) is a gene product with conserved catalytic activities and it promotes the progression of DNA damage. The α isoform is present in proliferating cells. [1]
Topoisomerase II α is encoded by TOP2A gene, which is located on 17q21.2 in the human chromosome. It is essential for controlling the topological state of DNA by reversibly breaking the DNA strands during replication, recombination and transcription. TOP2A expression increases at late S phase and during G2/M of the cell cycle and decreases after mitosis.[2] Polymorphism with TOP2A causes chromosome instability and tumorigenesis.[3] TOP2A causes tumor proliferation and invasiveness in various cancer types like breast cancer, ovarian cancer and prostate cancer.[4]
Anwendung
Human topoisomerase II α has been used in DNA cleavage assay.[5]
Biochem./physiol. Wirkung
Used to study DNA structure and topology.
Einheitendefinition
One unit will decatenate 0.2 μg of kinetoplast DNA in 30 minutes at 37°C.
Physikalische Form
Buffered aqueous glycerol solution, containing Trizma buffer (pH 7.7). Other components are present in the solution, and lot-specific information on these components may be obtained from Technical Service.
Angaben zur Herstellung
Recombinant enzyme overexpressed in a proprietary eukaryotic cell line.
Rechtliche Hinweise
TOPO is a registered trademark of Life Technologies
Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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J R Spitzner et al.
Nucleic acids research, 16(12), 5533-5556 (1988-06-24)
Topoisomerase II, purified from chicken erythrocytes, was reacted with a large number of different DNA fragments and cleavages were catalogued in the presence and absence of drugs that stabilize the cleavage intermediate. Cleavages were sequenced to derive a consensus for
TOP2A induces malignant character of pancreatic cancer through activating beta-catenin signaling pathway.
Pei YF, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(1), 197-207 (2018)
Raj Kumar Mandraju et al.
Archives of biochemistry and biophysics, 470(1), 27-34 (2007-11-21)
Topoisomerase II alpha (TopoIIalpha) and Topoisomerase II beta (TopoIIbeta) isoforms are different gene products having conserved catalytic activities. The alpha isoform is present in proliferating cell, while beta isoform is predominantly present in non-proliferating cells namely neurons suggesting its role
Topoisomerase 2 alpha: a real predictor of anthracycline efficacy?
Romero A, et al.
Clinical And Translational Oncology, 14(3), 163-168 (2012)
The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer.
An X, et al.
BMC Cancer, 18(1), 331-331 (2018)
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