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SRP0290
Cathepsin F Active human
recombinant, expressed in FreeStyle™ 293-F cells, ≥90% (SDS-PAGE)
Synonym(e):
CATSF, CLN13
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50 μG
596,00 €
About This Item
Empfohlene Produkte
Rekombinant
expressed in FreeStyle™ 293-F cells
Assay
≥90% (SDS-PAGE)
Form
aqueous solution
Spezifische Aktivität
≥18 pmol/min-μg
Mol-Gew.
53 kDa
Methode(n)
activity assay: suitable
Löslichkeit
soluble
water: soluble
NCBI-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
human ... CTSF(8722)
Allgemeine Beschreibung
Research area: CELL SIGNALING
Human cathepsin F (GenBank Accession No. NM_003793), CD33 signal peptide(amino acids 1-16) + cathepsin S (amino acids 20-end), with C-terminal HIS tag, MW = 53 kDa (more than 58 kDa after post-modification), expressed in FreeStyle 293-F cells.
Human cathepsin F (GenBank Accession No. NM_003793), CD33 signal peptide(amino acids 1-16) + cathepsin S (amino acids 20-end), with C-terminal HIS tag, MW = 53 kDa (more than 58 kDa after post-modification), expressed in FreeStyle 293-F cells.
Anwendung
Active human cathepsin F is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Active human cathepsin F has been used in a study to assess its implications for the development of novel immunomodulators. [1] Active human cathepsin F has also been used in a study to investigate microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease. [2]
Biochem./physiol. Wirkung
Cathepsin F (CtsF) are endopeptidases that play a role in lysosomal protein degradation. Beyond its involvement in protein recycling, CtsF has also been associated with immune responses mediated by Toll-like receptors (TLRs) and antigen processing.[3] Additionally, mutation in the cathepsin F gene is related to the development of familial papillary thyroid cancer [4], type B Kufs disease, defective lysosomal degradation and abnormal autophagy, and Alzheimer′s disease.[5]
Einheitendefinition
One unit is defined as the amount of enzyme that will cleave 1 pmol of substrate per min at 37°C
Physikalische Form
Formulated in 45 mM sodium acetate, 135 mM NaCl and 10% glycerol.
Angaben zur Herstellung
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
Rechtliche Hinweise
FreeStyle is a trademark of Invitrogen Corp.
Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Cathepsins in the Pathophysiology of Mucopolysaccharidoses: New Perspectives for Therapy
Pasquale VD, et al.
Cells, 9(4), 979-979 (2020)
Cathepsin F genetic mutation is associated with familial papillary thyroid cancer
Wang Y, et al.
Journal of Separation Science, 364(4), 414-424 (2022)
Celine V M Cluzeau et al.
Human molecular genetics, 21(16), 3632-3646 (2012-05-24)
Niemann-Pick disease type C (NPC) is a lysosomal storage disorder characterized by liver disease and progressive neurodegeneration. Deficiency of either NPC1 or NPC2 leads to the accumulation of cholesterol and glycosphingolipids in late endosomes and early lysosomes. In order to
Salma Teimoori et al.
Parasitology international, 66(4), 443-447 (2016-05-04)
Diagnosis of Opisthorchis viverrini infection by conventional stool examination is increasingly difficult due to the low intensity of the infection after several rounds of control programmes in endemic regions as well as coinfections with intestinal flukes. Therefore sensitive and specific
The Crystal Structure of Human Cathepsin F and Its Implications for the Development of Novel Immunomodulators
Somoza JR, Palmer JT, Ho JD.
Journal of Molecular Biology, 322(3), 559-568 (2012)
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