SML1977

J113863, cis isomer

>97% (HPLC)

• Synonym(e): 1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide, Piperidinium, 1-(1-cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethyl-, iodide (1:1), cis-
• Empirische Formel (Hill-System): C₃₀H₃₇Cl₂IN₂O₂
• CAS-Nummer: 202796-41-6
• Molekulargewicht: 655.44
• MDL-Nummer: MFCD09971133
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: >97% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• InChI: 1S/C30H36Cl2N2O2.HI/c1-2-34(20-21-8-6-4-3-5-7-9-21)16-14-24(15-17-34)33-30(35)29-25-18-22(31)10-12-27(25)36-28-13-11-23(32)19-26(28)29;/h8,10-13,18-19,24,29H,2-7,9,14-17,20H2,1H3;1H/b21-8+;/t24-,34+;
• InChIKey: FOAFBMYSXIGAOX-KEKKVSGZSA-N

Beschreibung

Biochem./physiol. Wirkung

High affinity antagonist for CCR1 and CCR3 receptors, agonist at CCR2 and CCR5 receptors

J113863 is a high affinity antagonist for CCR1 and CCR3 receptors. Also both J113863 and its enantiomer c exhibit low binding affinity toward CCR2 and CCR5 where they activate three G_i and two G₀ protein isoforms. J113863 does not activate G₁₂ protein isoform. J113863 binding to CCR2 and CCR5 induce the recruitment of b-arrestin 2 whereas UCB35625 did not. J113863 and UCB35625 are biased ligands for the chemokine receptors CCR2 and CCR5.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable