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SML0517

Sigma-Aldrich

Amlexanox

≥98% (HPLC)

Synonym(e):

2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridin-3-carbonsäure

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10 MG
114,00 €
50 MG
425,00 €

114,00 €

Versandbereit am16. April 2025Details

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10 MG
114,00 €
50 MG
425,00 €

About This Item

Empirische Formel (Hill-System):
C16H14N2O4
CAS-Nummer:
68302-57-8
Molekulargewicht:
298.29
MDL-Nummer:
MFCD00864790
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825526
NACRES:
NA.77

114,00 €

Versandbereit am16. April 2025Details

Bulk-Bestellung anfordern

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 10 mg/mL at warmed, clear

Versandbedingung

wet ice

Lagertemp.

−20°C

SMILES String

CC(C)c1ccc2Oc3nc(N)c(cc3C(=O)c2c1)C(O)=O

InChI

1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)

InChIKey

SGRYPYWGNKJSDL-UHFFFAOYSA-N

Angaben zum Gen

human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

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Allgemeine Beschreibung

Amlexanox is an anti-allergic drug with anti-inflammatory properties.[1]

Biochem./physiol. Wirkung

Amlexanox elevates the amount of nonsense-containing mRNAs in treated cells and helps to generate full-length proteins effectively.[1]
Amlexanox is an anti-allergy and anti-asthma drug that blocks histamine and leukotriene release from leukocytes and mast cells. Amlexanox has also been shown to inhibit cahaperone activity of Hsp90, and S100A13, which is involved in transport of proteins devoid of signal peptide sequences.
Amlexanox is an anti-allergy, anti-ulcer drug; S100A13 inhibitor.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000390398
0000383510
0000390398
0000383510
0000163464

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Die Dokumentenbibliothek aufrufen

Shannon M Reilly et al.
Nature medicine, 19(3), 313-321 (2013-02-12)
Emerging evidence suggests that inflammation provides a link between obesity and insulin resistance. The noncanonical IκB kinases IKK-ɛ and TANK-binding kinase 1 (TBK1) are induced in liver and fat by NF-κB activation upon high-fat diet feeding and in turn initiate
B Murray et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 35(2), 117-122 (2006-01-25)
The study was designed to determine the efficacy of OraDisc (active component 2 mg amlexanox) on the prevention of aphthous ulcers treated at the prodromal stage. Thermographic imaging was used to confirm the presence of a prodromal ulcer. Fifty-two patients
Miki Okada et al.
Biochemical and biophysical research communications, 292(4), 1023-1030 (2002-04-12)
S100 proteins are a multigenic family of low-molecular-weight Ca(2+)-binding proteins comprising 19 members. These proteins undergo a conformational change by Ca(2+)-binding and consequently interact with their target proteins. Recently, we reported that two antiallergic drugs, Amlexanox and Cromolyn, bind to
F Tarantini et al.
The Journal of biological chemistry, 276(7), 5147-5151 (2000-11-23)
Interleukin (IL)1alpha mediates proinflammatory events through its extracellular interaction with the IL1 type I receptor. However, IL1alpha does not contain a conventional signal peptide sequence that provides access to the endoplasmic reticulum-Golgi apparatus for secretion. Thus, we have studied the
R W Barrons
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 58(1), 41-50 (2001-02-24)
The clinical features, etiology, and treatment of recurrent aphthous ulcers (RAU) are discussed. Aphthous ulcers are among the most common oral lesions in the general population, with a frequency of up to 25% and three-month recurrence rates as high as
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