R0382

Retrorsin

≥90% (HPLC), powder, retronecine-type pyrrolizidine alkaloid

• Synonym(e): β-Longilobin, 2,18-Dihydroxy-senecionan-11,16-dion
• Empirische Formel (Hill-System): C₁₈H₂₅NO₆
• CAS-Nummer: 480-54-6
• Molekulargewicht: 351.39
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24899338
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Retrorsin, ≥90% (HPLC)
• Assay: ≥90% (HPLC)
• mp (Schmelzpunkt): 208-211 °C (lit.)
• SMILES String: C\C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23
• InChI: 1S/C18H25NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,23H,5-10H2,1-2H3/b12-3-/t11-,14-,15-,18-/m1/s1
• InChIKey: BCJMNZRQJAVDLD-CQRYIUNCSA-N

Beschreibung

Anwendung

Retrorsine has been used:

• as a mito-inhibitory pyrrolizidine alkaloid compound to induce necrotic liver injury in rats[1]
• to induce hepatocellular injury in rats[2]
• to arrest endogenous hepatocyte growth in mice[3]

Biochem./physiol. Wirkung

Retrorsine (RTS) is a retronecine-type pyrrolizidine alkaloid associated with Senecio and Crotalaria species. It belongs to the pyrrolizidine alkaloid family[1] with mito-inhibitory property and elicits hepatotoxicity.[4] It mediates the inactivation of cytochrome P450 3A4.[4] Retrorsine also inhibits replication of fully differentiated hepatocytes.[2]

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300 + H310 + H330
• P-Sätze: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Gefahreneinstufungen: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges