SML0362

NPS2143 hydrochloride

≥98% (HPLC)

• Synonym(e): 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1), NPS-2143 hydrochloride, SB-262470-A hydrochloride
• Empirische Formel (Hill-System): C₂₄H₂₅ClN₂O₂ · HCl
• CAS-Nummer: 324523-20-8
• Molekulargewicht: 445.38
• MDL-Nummer: MFCD16038896
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825364
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]20/D +20 to +24°, c = 1.0 in methanol
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: >10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
• InChI: 1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
• InChIKey: ZEBNDUQLNGYBNL-VEIFNGETSA-N

Beschreibung

Anwendung

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :

• In the regulation of intestinal calcium transport.[1]
• In the regulation of local negative feedback of intestinal calcium absorption.[2]
• In sensorimotor decision making during development.[3]

Biochem./physiol. Wirkung

NPS2143 is a phenylalkylamine calcilytic compound,[4] and might be useful in treating autosomal dominant hypocalcemia.[5] It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.[6]

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist.

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC₅₀ of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302 + H312 + H332,H410
• P-Sätze: P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable