SML0314

CGP77675

≥98% (HPLC)

• Synonym(e): 1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol, 1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol, CGP 77675, CGP-77675
• Empirische Formel (Hill-System): C₂₆H₂₉N₅O₂
• CAS-Nummer: 234772-64-6
• Molekulargewicht: 443.54
• MDL-Nummer: MFCD20039929
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825319
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: >10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: COc1cccc(c1)-c2cn(-c3ccc(CCN4CCC(O)CC4)cc3)c5ncnc(N)c25
• InChI: 1S/C26H29N5O2/c1-33-22-4-2-3-19(15-22)23-16-31(26-24(23)25(27)28-17-29-26)20-7-5-18(6-8-20)9-12-30-13-10-21(32)11-14-30/h2-8,15-17,21,32H,9-14H2,1H3,(H2,27,28,29)
• InChIKey: WUPXZZWTHIZICK-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

CGP77675 belongs to the pyrrolopyrimidine class of inhibitors.[1]

Anwendung

CGP77675 has been used in the generation of mouse expanded potential stem cells.[2]

Biochem./physiol. Wirkung

CGP77675 is a potent Src kinase inhibitor.

CGP77675 is a potent Src kinase inhibitor. CGP77675 is selective toward other protein kinases including Cdc2 (>500-fold), epidermal growth factor (EGF) receptor (7.5-fold), vascular endothelial growth factor receptor (>50-fold), and for v-Abl (15-fold) and focal adhesion kinase (Fak) (>25-fold).

CGP77675 prevents hypercalcemia stimulated by interleukin 1β. It is known to offer protection against bone loss in ovariectomized mice.[1] CGP77675 is known for its use in cancer treatment.[3]

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable