Q3251

Quinacrin -dihydrochlorid

≥90% (TLC), powder, MAO-A/B inhibitor

• Synonym(e): 6-Chlor-9-(4-diethylamino-1-methylbutylamino)-2-methoxy-acridin -dihydrochlorid, Atebrin -dihydrochlorid, Mepacrin -dihydrochlorid, Quinacrin -dihydrochlorid
• Empirische Formel (Hill-System): C₂₃H₃₀ClN₃O · 2HCl
• CAS-Nummer: 69-05-6
• Molekulargewicht: 472.88
• Beilstein: 4834013
• EG-Nummer: 200-700-8
• MDL-Nummer: MFCD00012659
• UNSPSC-Code: 12352101
• PubChem Substanz-ID: 24278192
• NACRES: NA.77

Eigenschaften

• product name: Quinacrin -dihydrochlorid, ≥90%
• Biologische Quelle: synthetic
• Assay: ≥90%
• Form: powder
• mp (Schmelzpunkt): 257 °C
• Löslichkeit: H₂O: soluble, clear to hazy
• Ersteller: Bayer
• SMILES String: Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
• InChI: 1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
• InChIKey: UDKVBVICMUEIKS-UHFFFAOYSA-N
• Angaben zum Gen: human ... MAOA(4128) , MAOB(4129)

Beschreibung

Allgemeine Beschreibung

Quinacrine is an acridine derivative and a potent antimalarial agent.

Anwendung

Quinacrine dihydrochloride has been used:

• in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
• in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
• in uptake-release assay for characterization of dense granule functionality of platelets

Biochem./physiol. Wirkung

Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases. Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections. It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.

Non-selective MAO-A/B inhibitor.

Leistungsmerkmale und Vorteile

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves