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P7903

Sigma-Aldrich

Pipemidinsäure

Synonym(e):

8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-pyrido[2,3-d]pyrimidin-6-carbonsäure

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About This Item

Empirische Formel (Hill-System):
C14H17N5O3
CAS-Nummer:
51940-44-4
Molekulargewicht:
303.32
EG-Nummer:
257-530-2
MDL-Nummer:
MFCD00057291
UNSPSC-Code:
51282938
PubChem Substanz-ID:
24898889
NACRES:
NA.85

Form

powder

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Wirkungsweise

DNA synthesis | interferes
cell wall synthesis | interferes
enzyme | inhibits

SMILES String

CCN1C=C(C(O)=O)C(=O)c2cnc(nc12)N3CCNCC3

InChI

1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)

InChIKey

JOHZPMXAZQZXHR-UHFFFAOYSA-N

Angaben zum Gen

human ... CYP1A2(1544)

Allgemeine Beschreibung

Chemical structure: quinolone

Anwendung

Pipemidic acid is used to study DNA damage and mutagenic activity. It has been used to induce articular lesions in the neonatal mouse and is used to study human lymphocyte blastogenesis and γ-interferon production .

Biochem./physiol. Wirkung

Pipemidic acid modulates (inhibits) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Pipemidic acid has been shown to induce inhibition of lymphocyte DNA synthesis.

Hinweis zur Analyse

Very slightly soluble in water. It dissolves in diluted solutions of acids and of alkali hydroxides.

Sonstige Hinweise

10g,100g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H317,H334

Gefahreneinstufungen

Resp. Sens. 1 - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Xiao X Han et al.
Analytical chemistry, 81(9), 3350-3355 (2009-04-14)
For surface-enhanced Raman scattering (SERS)-based protein identification, immunoassay, and drug screening, metal sandwich substrates bridged by proteins have been created in the present study. The sandwich architectures are fabricated based on a layer-by-layer (LbL) technique. The first gold monolayer is
Quinolone-Induced Arthropathy in the Neonatal Mouse: Morphological Analysis of Articular Lesions Produced by Pipemidic Acid and Ciprofloxacin1
DANIEL A. LINSEMAN, LAURIE A. HAMPTON, et al.
Toxicological Sciences, 28, 59-64 (1995)
I Grabnar et al.
International journal of pharmaceutics, 322(1-2), 52-59 (2006-06-30)
Intravesical administration of cytotoxic agents is commonly used in urological practice for treatment of superficial bladder cancer. The leading motive is optimisation of drug delivery near the site of action and reduction of systemic toxicity. Bladder pharmacokinetics is complicated by
Adrián Jaén-Gil et al.
Journal of chromatography. A, 1568, 57-68 (2018-06-19)
The evaluation of wastewater treatment capabilities in terms of removal of water pollutants is crucial when assessing water mitigation issues. Not only the monitoring of target pollutants becomes a critical point, but also the transformation products (TPs) generated. Since these
Adrienne B Hoeglund et al.
Journal of medicinal chemistry, 53(3), 1056-1066 (2010-01-01)
Autotaxin (ATX, NPP2) has recently been shown to be the lysophospholipase D responsible for synthesis of the bioactive lipid lysophosphatidic acid (LPA). LPA has a well-established role in cancer, and the production of LPA is consistent with the cancer-promoting actions
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