N193

1-Naphthylacetyl spermine trihydrochloride

• Synonym(e): NASPM trihydrochloride
• Empirische Formel (Hill-System): C₂₂H₃₄N₄O · 3HCl
• CAS-Nummer: 1049731-36-3
• Molekulargewicht: 479.91
• MDL-Nummer: MFCD01321052
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24897539
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Qualitätsniveau: 100
• Form: powder
• Lagerbedingungen: desiccated; protect from light
• Farbe: white
• Löslichkeit: H₂O: ≥20 mg/mL
• SMILES String: Cl.Cl.Cl.NCCCNCCCCNCCCNC(=O)Cc1cccc2ccccc12
• InChI: 1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H
• InChIKey: JNEOJAUJWOPWJS-UHFFFAOYSA-N

Beschreibung

Anwendung

1-Naphthylacetyl spermine trihydrochloride has been used for the inhibition of calcium-permeable AMPAR (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor).[1] It has also been used to study the involvement of AMPAR in biphasic activation of stress-activated protein kinase/extracellular signal-regulated kinase-1.[2]

Biochem./physiol. Wirkung

Blocks Ca²⁺ permeable AMPA receptor channels.

Sonstige Hinweise

Synthetic analog of Joro spider toxin.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)