M5269

Moniliformin sodium salt from Fusarium proliferatum

• Synonym(e): 1-Hydroxycyclobut-1-ene-3,4-dione
• Lineare Formel: C₄HO₃Na
• CAS-Nummer: 71376-34-6
• Molekulargewicht: 120.04
• MDL-Nummer: MFCD00056566
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24896991
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Lagertemp.: 2-8°C
• SMILES String: O=C1C(C=C1[O-])=O.[Na+]
• InChI: 1S/C4H2O3.Na/c5-2-1-3(6)4(2)7;/h1,5H;/q;+1/p-1
• InChIKey: FERDNJVXTWPNSA-UHFFFAOYSA-M

Beschreibung

Allgemeine Beschreibung

Moniliformin (MON), a mycotoxin[1] and small ionic molecule[2], is present in various Fusarium species including Fusarium avenaceum, Fusarium subglutinans and Fusarium proliferatum.[1] It is present as sodium or potassium salt of semisquaric acid naturally.[1] MON is also present in maize and small-grain cereals.[2]

Anwendung

Moniliformin sodium salt from Fusarium proliferatum has been used as a mycotoxin standard:

• to test its acute oral toxicity in mice[1]
• to test its subacute toxic effects in rats[2]
• in characterizing mycotoxins from Aspergillus[3]

Biochem./physiol. Wirkung

Moniliformin (MON) is implicated for its toxic potential and may lead to respiratory distress and progressive muscular weakness in rats.[1] It inhibits the tricarboxylic acid (TCA) cycle oxidation step.[1] By acting as a pyruvate substrate, MON effectively inhibits thiamine pyrophosphate cofactor dependant enzymes and blocks the gluconeogenesis pathway.[1] ) Furthermore, MON also inhibits glutathione peroxidase and glutathione reductase leading to oxidative stress in myoblast.[2]

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P301 + P310
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges