This product, Intralipid, is a lipid emulsion comprising soybean oil.
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Wichtige Dokumente
I141
Intralipid
emulsion, lipid emulsion
Synonym(e):
Phospholipidstabilisiertes Sojabohnenöl
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100 ML
215,00 €
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100 ML
215,00 €
About This Item
Empfohlene Produkte
Produktbezeichnung
Intralipid, 20%, emulsion
Form
emulsion
Konzentration
20%
Farbe
white
Lagertemp.
2-8°C
Anwendung
Intralipid wurde wie folgt verwendet:
- zum Prüfen seiner optischen Eigenschaften zur Verwendung als Streumedium bei der Erzeugung von Gewebephantom[1]
- als eine Komponente von Agarosegelphantom zur Verringerung der Streuungskoeffizienten und Hintergrundabsorption[2]
- bei der Infusion in Mäuse bei Studien zu hyperinsulinämisch-euglykämischen Clamps zur Bewertung seiner Wirkung auf die Zirkulation von nicht veresterten freien Fettsäuren (NEFA)[3]
Biochem./physiol. Wirkung
Intralipid ist eine Lipidemulsion aus Sojabohnenöl. Es begünstigt die Produktion von proinflammatorischen Zytokinen und wird für die Behandlung von immunvermittelten Fehlgeburten und Implantationsfehlern empfohlen.[4] Bei der parenteralen Ernährung ist Intralipid die Fettquelle.[5] Es löst bei Ischämie-Reperfusionsschädigungen des Herzens einen Schutz aus, indem es die Porenöffnung der mitochondrialen Permeabilitätstransition hemmt.[6] Intralipid ist eine wirksame Alternative für intravenöses Immunglobulin und verbessert die Bioverfügbarkeit von Antikrebsmedikamenten auf Platinbasis.[7]
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves
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Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A
Li J, et al.
Anesthesiology, 117(4), 836-846 (2012)
Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice
Xu W, et al.
Molecular and Cellular Endocrinology, 482(22), 1-10 (2019)
Birgitta I Zielbauer et al.
Journal of colloid and interface science, 529, 197-204 (2018-06-13)
Oleosomes are stabilized by a complex outer phospholipid-protein-layer. To improve understanding of its structure and stabilization mechanism, this shell has to be studied in extracellular native conditions. This should be possible by SANS using contrast variation. Oleosomes are expected to
Use of intralipid in the management of recurrent implantation failure: An overview
Khan L, et al.
Journal of natural science, biology, and medicine, 9(2), 111-111 (2018)
Lisa R Beutler et al.
eLife, 9 (2020-07-29)
Body weight is regulated by interoceptive neural circuits that track energy need, but how the activity of these circuits is altered in obesity remains poorly understood. Here we describe the in vivo dynamics of hunger-promoting AgRP neurons during the development
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Hi I did use freeze-dry to convert intralipid to powder but what I have now is liquid, I was wondering that the intralipid is water base or oil base? because that makes difference in my research. Thnaks
1 Antwort-
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I need to prepare a 500 ml phantom using Intralipid 20% and distilled water. How much Intralipid 20% should I add to the distilled water to achieve a reduced scattering coefficient of 8 cm−1?
1 Antwort-
Unfortunately, the scattering coefficient of this material has not been determined. The scattering coefficient of Intralipid 20% can vary due to differences in the concentrations of soybean oil, glycerin, phospholipids, free fatty acids, and pH between batches. Regarding the determination of the scattering coefficient in distilled water and establishing a reference value, the following citation from Biomedical Optics Express (2021) may be of interest.
Biomed Opt Express. 2021 Oct 7;12(11):6814-6830.
Investigation of methods to extract confocal function parameters for the depth-resolved determination of attenuation coefficients using OCT in intralipid samples, titanium oxide phantoms, and in vivo human retinas
https://pubmed.ncbi.nlm.nih.gov/34858682/Hilfreich?
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Hi. Do you know what is extinction coefficient at 680 nm and molecular weight of this product? Thank you
1 Antwort-
Unfortunately, the extinction coefficient is not determined for this product. This is a multi-component material containing a range of fatty acids and phospholipids, the molecular weight is not available.
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Hello, I am using IL-20 for tissue phantoms. Is the 20% concentration a volume/volume concentration or something different?
1 Antwort-
The concentration is specified as 20% weight/weight (w/w).
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Is this solution sterile?
1 Antwort-
Yes. Intralipid 20% is a sterile product. The product is sterilized in its final container.
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Is there a concentration for Intralipid 20% in mg/mL? Or a density value in order to calculate concentration in mg/mL?
1 Antwort-
The density of Intralipid, 20% is 0.99 g/mL at room temperature. The "20%" in the product name is a nominal value; the specification for the concentration is 18.0 to 22.0 percent on a weight-to-weight basis. Based on a density of 0.99 g/mL, that would convert to a weight-to-volume percentage of soybean oil of 17.8 to 21.8 percent, or 178-218 g/mL.
Please navigate to the DOCUMENTATION section of the Product Detail Page to access a Certificate under ‘Certificate of Analysis’:
https://www.sigmaaldrich.com/product/sigma/i141#product-documentationHilfreich?
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Is there a shelf life for this product or after opening?
1 Antwort-
This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
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What are the components of Product I141, Intralipid?
1 Antwort-
This Intralipid is made up of 20% soybean oil, 1.2% egg yolk phospholipids and 2.25% glycerin; the remainder is water.
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Can Product I141, Intralipid, be used in cell culture?
1 Antwort-
We have not tested this product for cell culture application. An article by Per Oscarsson, A., et al., Acta Anaesthesiol. Scand. 45, 1215-1220 (2001), used Intralipid in cell culture with primary cultured rat neurons at 1.0 mg/mL for 20 minutes.
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What is the Department of Transportation shipping information for this product?
1 Antwort-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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