H108

Hemicholinium-3

solid, ≥95% (HPLC)

• Synonym(e): 2,2′-(4,4′-Biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium bromide)
• Empirische Formel (Hill-System): C₂₄H₃₄Br₂N₂O₄
• CAS-Nummer: 312-45-8
• Molekulargewicht: 574.35
• Beilstein: 5704458
• EG-Nummer: 206-227-3
• MDL-Nummer: MFCD00011978
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278169
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: solid
• Farbe: white
• Löslichkeit: ethanol: 1.3 mg/mL; H₂O: 10 mg/mL
• SMILES String: [Br-].[Br-].C[N+]1(C)CCOC(O)(C1)c2ccc(cc2)-c3ccc(cc3)C4(O)C[N+](C)(C)CCO4
• InChI: 1S/C24H34N2O4.2BrH/c1-25(2)13-15-29-23(27,17-25)21-9-5-19(6-10-21)20-7-11-22(12-8-20)24(28)18-26(3,4)14-16-30-24;;/h5-12,27-28H,13-18H2,1-4H3;2*1H/q+2;;/p-2
• InChIKey: OPYKHUMNFAMIBL-UHFFFAOYSA-L

Beschreibung

Anwendung

Hemicholinium-3 has been used in the preparation of Krebs-HC-3 buffer to study its effects on choline uptake and choline acetyltransferase activity in differentiated human neuroblastoma (SK-N-SH) cells.

Biochem./physiol. Wirkung

Hemicholinium-3 plays a role in blocking the neuronal choline uptake thereby inhibiting acetylcholine synthesis in the brain.

Leistungsmerkmale und Vorteile

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301 + H311 + H331,H315,H319,H335
• P-Sätze: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges