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27840

Sigma-Aldrich

Corticosteron

≥98.5% (HPLC)

Synonym(e):

11β,21-Dihydroxy-4-pregnen-3,20-dion, 11β,21-Dihydroxyprogesteron, 4-Pregnen-11β,21-diol-3,20-dion, Kendall’s Compound B, Reichstein’s Substance H

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100 MG
34,70 €
500 MG
125,00 €

34,70 €

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100 MG
34,70 €
500 MG
125,00 €

About This Item

Empirische Formel (Hill-System):
C21H30O4
CAS-Nummer:
50-22-6
Molekulargewicht:
346.46
Beilstein:
2339601
EG-Nummer:
200-019-6
MDL-Nummer:
MFCD00037715
UNSPSC-Code:
12352211
PubChem Substanz-ID:
57648276
NACRES:
NA.77

34,70 €

Versandbereit am09. April 2025Details

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Biologische Quelle

synthetic

Assay

≥98.5% (HPLC)

Form

powder or crystals

Optische Aktivität

[α]20/D +223±3°, c = 1% in ethanol

mp (Schmelzpunkt)

179-183 °C (lit.)
179-183 °C

Funktionelle Gruppe

ketone

SMILES String

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChIKey

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Angaben zum Gen

human ... EBP(10682) , SERPINA6(866)
rat ... Ar(24208) , Nr3c1(24413)

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Allgemeine Beschreibung

Corticosterone (Cort) is a glucocorticoid hormone.[1] It is also the principal hormone that mediates stress responses in birds.[2] It is the primary adrenal cortical steroid in rat plasma.[3] The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.[4]

Anwendung

Corticosterone was used to study the adrenoceptor signaling in rats,[5][6] lizards[7] or in vitro.[8] It was also used in immune suppression experiment.[9]

Biochem./physiol. Wirkung

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.[10][11]

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Angaben zur Herstellung

Corticosterone is soluble in chloroform and ethanol.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCN0044
BCCL4200
BCCJ6406
BCCG4194
BCCF3447

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Die Dokumentenbibliothek aufrufen

Stress, corticosterone responses and avian personalities.
Cockrem JF.
Journal of Ornithology, 148(2), 169-178 (2007)
Corticosterone and brood abandonment in a passerine bird.
Ouyang JQ, et al.
Animal behaviour, 84(1), 261-268 (2012)
Amanda J Rickard et al.
Journal of molecular endocrinology, 42(6), 449-459 (2009-01-23)
The mineralocorticoid receptor (MR) and glucocorticoid receptor are ligand-activated transcription factors that have important physiological and pathophysiological actions in a broad range of cell types including monocytes and macrophages. While the glucocorticoids cortisol and corticosterone have well-described anti-inflammatory actions on
D F DeNardo et al.
Hormones and behavior, 27(2), 184-199 (1993-06-01)
Adrenal corticoid release is a major component of the stress response which can affect many body functions including behavior. The purpose of our studies was to examine the effects of corticosterone (B) on both the agonistic and courtship components of
Bryan E LaFonte et al.
The Journal of experimental biology, 216(Pt 19), 3700-3708 (2013-07-04)
Although naturally occurring hosts often exhibit pronounced differences in infection and pathology, the relative importance of factors associated with host life history and immunity in explaining such patterns often remains speculative. Research in eco-immunology highlights the trade-offs between host physiology
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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 Antwort

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 Antwort

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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