G8415

L-Glutaminsäure

98.5-100.5%, suitable for cell culture, non-animal source, meets EP testing specifications

• Synonym(e): (S)-2-Amino-glutarsäure, Glu
• Lineare Formel: HO₂CCH₂CH₂CH(NH₂)CO₂H
• CAS-Nummer: 56-86-0
• Molekulargewicht: 147.13
• Beilstein: 1723801
• EG-Nummer: 200-293-7
• MDL-Nummer: MFCD00002634
• UNSPSC-Code: 12352209
• eCl@ss: 32160406
• PubChem Substanz-ID: 24895340
• NACRES: NA.26

Eigenschaften

• Produktbezeichnung: L-Glutaminsäure, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%
• Biologische Quelle: non-animal source
• Qualitätsniveau: 300
• Agentur: meets EP testing specifications
• Assay: 98.5-100.5%
• Form: powder
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: endotoxin, tested
• Farbe: white
• mp (Schmelzpunkt): 205 °C (dec.) (lit.)
• Löslichkeit: 1 M HCl: 100 mg/mL
• Dichte: 1.54 g/cm³ at 20 °C
• Anionenspuren: chloride (Cl^-): ≤200 ppm; sulfate (SO₄^2-): ≤200 ppm
• Kationenspuren: As: ≤1 ppm, passes test; Fe: ≤10 ppm, passes test; NH₄⁺: ≤200 ppm, passes test
• Anwendung(en): pharmaceutical (small molecule)
• SMILES String: N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• InChIKey: WHUUTDBJXJRKMK-VKHMYHEASA-N
• Angaben zum Gen: human ... CCR2(1231) , GRIA1(2890) , GRIA2(2891) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK5(2901) , GRIN2B(2904) , GRM2(2912) , SLC1A1(6505) , SLC1A2(6506) ; rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm3(24416) , Grm4(24417) , Grm5(24418) , Grm6(24419) , Grm7(81672) , Slc1a2(29482)

Beschreibung

Anwendung

L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line.[1][2][3]

Biochem./physiol. Wirkung

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid.[4] Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity.[5] It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids.[5][6] In cells, glutamine is converted to glutamate by the enzyme glutaminase.[6] Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.[5]

Ein exzitatorischer Aminosäure-Neurotransmitter, der ein Agonist an allen Subtypen der Glutamat-Rezeptoren (metabotropen, Kainat, NMDA und AMPA) ist.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)